帮我介绍下以下这个蛋白的结构、功能、疾病、背景研究方面信息：
中文名称:高迁移率族蛋白B1 英文全称:High Mobility Group Protein B1 简称:HMGB-1
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HMGB1, or High Mobility Group Protein B1, is a highly conserved nuclear protein found in all eukaryotic cells. With a molecular weight of 25 kilodaltons and consisting of 215 amino acids, HMGB1 serves dual roles as both a chromatin architectural protein within the nucleus and an important danger signal when released extracellularly. This protein plays crucial roles in DNA organization, gene regulation, and immune responses.