activation of lysosomal iron trigger ferroptosis in cancer ，published in nature in 7/5 2025, summary the article and create a video

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Cancer remains one of the most challenging diseases to treat, with cancer cells often developing resistance to conventional therapies. However, recent groundbreaking research published in Nature reveals a promising new approach: targeting lysosomal iron to trigger ferroptosis in cancer cells. This discovery could revolutionize how we fight cancer by exploiting a fundamental weakness in cancer cell metabolism. Ferroptosis is a unique form of programmed cell death that differs from traditional apoptosis and necrosis. It is characterized by iron-dependent lipid peroxidation that leads to membrane damage and ultimately cell death. The process involves the accumulation of iron ions, which catalyze the formation of reactive oxygen species, causing oxidative damage to cellular membranes. Cancer cells are particularly vulnerable to ferroptosis due to their altered iron metabolism and increased oxidative stress. The key breakthrough discovery reveals how lysosomes, the cellular organelles responsible for storing and regulating iron levels, can be manipulated to trigger ferroptosis specifically in cancer cells. Researchers found that when lysosomal iron is released into the cytoplasm, it becomes available to catalyze the lipid peroxidation process that leads to ferroptosis. This creates a targeted vulnerability in cancer cells that can be exploited for therapeutic purposes, offering a new approach to cancer treatment. The beauty of this approach lies in its selectivity. Cancer cells have fundamentally different iron metabolism compared to normal cells. They have higher iron demands, altered iron regulation, and are more vulnerable to ferroptosis. In contrast, normal cells maintain balanced iron levels and have better antioxidant defenses that protect them from ferroptosis. This fundamental difference allows researchers to selectively target cancer cells while sparing healthy tissue, making lysosomal iron targeting a promising therapeutic strategy. This groundbreaking research on lysosomal iron and ferroptosis represents a major advancement in cancer treatment. By targeting lysosomal iron to trigger ferroptosis specifically in cancer cells while sparing normal cells, this approach opens new therapeutic pathways that could overcome resistance to conventional therapies. This discovery represents a paradigm shift in cancer research, offering hope for more effective and selective cancer treatments in the future.